학술논문
NIR dye-loaded mesoporous silica nanoparticles for a multifunctional theranostic platform: Visualization of tumor and ischemic lesions, and performance of photothermal therapy
Document Type
Article
Author
Source
Journal of Industrial and Engineering Chemistry, 88(0), pp.99-105 Aug, 2020
Subject
Language
English
ISSN
1876-794X
1226-086X
1226-086X
Abstract
We report the fabrication of multifunctional theranositic biomaterials via non-covalent, rapid, andeffective encapsulation of 1,10dioctadecyl-3,3,30,30-tetrametylindotrucarbocyanine iodide (DIR)onto mesoporous silica nanoparticles by coating the surface of polyethylene glycol (PEG-DIR@MSN). PEG-DIR@MSNs exhibited great stability with excellent biocompatibility and photothermal conversionproperties. PEG-DIR@MSN allowed for not only the detection of various types of tumor and ischemiclesions but also photothermal therapy against breast cancer in living mice, suggesting that PEGDIR@MSN is a valuable multifunctional theranostic platform.