부산대학교 도서관

Background: The gut microbial dysbiosis and gender differences in the pathogenesis of acne vulgaris have long been postulated respectively. However, there was no data about a gender- related discrepancy in gut microbiota and microbial metabolism in acne. Objective: This study aimed at identifying the underlying gender-related difference in gut mi- crobiota and metabolism in acne vulgaris. Methods: Fecal samples were collected from 43 acne patients and 43 age and gender-matched controls. Gut microbiota was analyzed by sequencingthe V3-V4 regionof gene and microbial metabolites were quantitatively detected using gas chromatography time-of-flight mass spectrometry. Results: Compared with healthy controls, the men had a lower abundance of 18 microbes such as Butyricicoccus Clostridium sensu stricto Faecalibaculum Bacillus Lactococcus Blautia Clostridiales Lachnospiracea incertae sedis Ruminococcus at genus level. However, the female patients only showed increased Clostridium sensu stricto and declined Oscilli-bacter Odoribacterin. Additionally, the disordered metabolism of fatty acids was identi- fied in male patients, while the dysbiosis of amino acids metabolism in female ones.Conclusion: The disorder of gut microbiota and metabolism in acne vulgaris was gender- specific, which supported the potential role of gender difference in the pathogenesis of this disease.