부산대학교 도서관

Purpose: We investigated maternal genetic effects of four IL-4/IL-13 pathway genes as well as their interactions with the “Western or Easternlifestyles/environments” on IgE in Karelian children. Methods: This study included 609 children and their mothers. Total IgE levels in children andmothers were measured and 10 single nucleotide polymorphisms (SNPs) in IL-4, IL-4Ra, IL-13, and STAT6 were genotyped in mothers and their children. Results: The maternal G allele of IL-13 130 (rs20541) was significantly (P=0.001) associated with decreased IgE in children in the Karelianpopulation (Pooling Finnish and Russian children), as well as in Finnish (P=0.030) and Russian children (P=0.018). The IgE levels were significantly(P=0.001) higher in Russian children whose mothers were homozygous for the G allele of the IL-4Ra 50 (rs1805010) SNP than that in Russian childrenof mothers who were AG heterozygotes or AA homozygotes. After accounting for children’s genotypes, we observed interactive effects on children’sIgE for maternal IL-13 130 genotypes (P=0.014) and maternal IL-4Ra 50 genotypes (P=0.0003) with “Western or Eastern” lifestyles/environments. With the adjustment for multiple comparisons using a false discovery rate (FDR) of 0.05, the interactive effect of the maternal IL-4Ra 50 SNP wassignificant. Conclusion: Maternal genetic variants in IL-4/IL-13 pathway genes, such as IL-13 130 and IL-4Ra50, influenced IgE levels in schoolchildren that were independent of the children’s genetic effects. These effects differ in “Western or Eastern” environments.