부산대학교 도서관

Background and Purpose Whether or not migraine can cause cumulative brain alterationsdue to frequent migraine-related nociceptive input in patients is largely unclear. The aim of thisstudy was to characterize longitudinal changes in brain activity between repeated observationswithin a short time interval in a group of female migraine patients, using resting-state functional magnetic resonance imaging. Methods Nineteen patients and 20 healthy controls (HC) participated in the study. Regionalhomogeneity (ReHo) and functional interregional connectivity were assessed to determine thefocal and global features of brain dysfunction in migraine. The relationship between changes inheadache parameters and longitudinal brain alterations were also investigated. Results All patients reported that their headache activity increased over time. AbnormalReHo changes in the patient group relative to the HC were found in the putamen, orbitofrontalcortex, secondary somatosensory cortex, brainstem, and thalamus. Moreover, these brain regions exhibited longitudinal ReHo changes at the 6-week follow-up examination. These headache activity changes were accompanied by disproportionately dysfunctional connectivity inthe putamen in the migraine patients, as revealed by functional connectivity analysis, suggesting that the putamen plays an important role in integrating diverse information among othermigraine-related brain regions. Conclusions The results obtained in this study suggest that progressive brain aberrations in migraine progress as a result of increased headache attacks.