부산대학교 도서관

Purpose: Streptococcus pneumoniae (S. pneumoniae) causes respiratory tract infections. Its non-vaccine serotypes and multidrug-resistant pneumococcal diseases have increased during the post-pneumococcal vaccination era. Therefore, it is importantto understand the regional and age-related antimicrobial susceptibility of S. pneumoniae to select appropriate empirical antimicrobials. Materials and Methods: We retrospectively studied trends in the antimicrobial resistance of S. pneumoniae to commonly prescribedantibiotics in patient groups of various ages at a single teaching hospital in Jeju Island from 2009 to 2018. Results: In total, 1460 S. pneumoniae isolates were obtained during the study period. The overall antimicrobial resistance rates ofS. pneumoniae to penicillin, erythromycin, ceftriaxone, levofloxacin, and vancomycin were 16.2%, 84.7%, 25.9%, 3.3%, and 0.0%,respectively, and the MDR rate was 6.7%. Erythromycin and ceftriaxone resistance rates increased by years; however, they weresignificantly reduced in adult groups. Levofloxacin resistance and MDR rates were also higher in adult groups. Overall, the MDRrate significantly increased during the recent 10 years, as well as in patients with a history of hospitalization within 90 days [oddsratio (OR)=3.58, 95% confidence interval (CI)=1.91–6.71] and sinusitis (OR=4.98, 95% CI=2.07–11.96). Conclusion: Erythromycin and ceftriaxone resistance rates and the MDR rate of S. pneumoniae significantly increased during therecent 10 years; the trends in individual antimicrobial resistance rates significantly differed between the age groups. This study indicatesthe need for caution when using ceftriaxone as an empirical antimicrobial against pneumococcal infections.