학술논문
INHIBITORY EFFECT OF SODIUM PENTOSAN POLYSULFATE ON THE FORMATION, GROWTH AND AGGREGATION OF CALCIUM OXALATE IN VITRO / 蓚酸カルシウム結晶形成, 成長, 凝集に対する Sodium Pentosan Polysulfate の阻止作用
Document Type
Journal Article
Author
Source
日本泌尿器科学会雑誌 / The Japanese Journal of Urology. 1989, 80(4):526
Subject
Language
Japanese
ISSN
0021-5287
1884-7110
1884-7110
Abstract
The inhibitory effects of sodium pentosan polysulfate (SPP)on the formation, growth and aggregation of calcium oxalate (CaOx)crystals were estimated by means of a Coulter counter TA II by the seed crystal method, whole urine method and infrared spectroscopic method.In the seeded crystal system, the inhibitory activities on aggregation (Ia), growth (Ig) and size (Is) were calculated from the change of the number, volume and diameter of crystals. At above 0. 5μg/ml, SPP inhibited the aggregation and growth of added CaOx monohydrate (COM) and dihydrate (COD) crystals.In the whole urine system, after determining the metastable limit, the formation and growth of CaOx crystals precipitated in response to a load of sodium oxalate was measured. SPP had a strong inhibitory effect on the formation and growth in the concentration of over 5μg/ml.In infrared spectroscopic study, the ratio of COD/COM formed in whole urine increased with the concentration of SPP.SPP therefore might have prevented the recurrence of stone formation.