부산대학교 도서관

A 64-year-old woman had a distal gastrectomy done 9 years prior for early gastric cancer ; on pathology, the diagnosis was por2>sig, T1 (SM), N2 (25/26), H0, P0 and Stage II. In March 2009, she developed a severe headache, nausea, and vomiting. A cerebrospinal fluid puncture was done adenocarcinoma cells were found, and meningeal carcinomatosis was diagnosed. Intramedullary administration of 10 mg methotrexate 6 times resulted in a remarkable decrease in the carcinoma cell count ; her headaches ceased. However, her general condition deteriorated. She developed multiple lung, liver and skin metastases. The patient died 102 days after being diagnosed. This paper reports a very rare case of leptomeningeal carcinomatosis in a patient treated for early gastric cancer.