학술논문
Dose-Dependent Inhibitory Effect of Rosuvastatin in Japanese Patients with Acute Myocardial Infarction on Serum Concentration of Matrix Metalloproteinases–INVITATION Trial–
Document Type
Journal Article
Author
Eiichiro Yamamoto; Hideki Maruyama; Hideki Shimomura; Hisao Ogawa; Ichiro Kajiwara; Jun Hokamaki; Kazuteru Fujimoto; Kenichi Tsujita; Kenji Sakamoto; Koichi Kaikita; Koichi Kikuta; Koichi Nakao; Koichiro Fujisue; Naritsugu Sakaino; Nobutaka Hirai; Nobuyasu Yamamoto; Ryusuke Tsunoda; Seiji Hokimoto; Shinichi Nakamura; Shinji Tayama; Shuichi Oshima; Shunichi Koide; Takuhiro Shirakawa; Tomohiro Sakamoto; Toshiyuki Matsumura; Toyoki Hirose; Yasuhiro Izumiya; Yasuhiro Nagayoshi
Source
Journal of Atherosclerosis and Thrombosis. 2022, 29(2):229
Subject
Language
English
ISSN
1340-3478
1880-3873
1880-3873
Abstract
Results: Between August 2017 and October 2018, 120 patients with AMI from 19 institutions were randomly assigned to either the appropriate-dose or the low-dose group. There were 109 patients who completed the 24-week follow-up. The primary endpoint for both MMP-2 and MMP-9 was not significantly different between the two groups. The change in the active/total ratio of MMP-9 at week 12 after baseline was significantly lower in the appropriate-dose group compared with the low-dose group (0.81 [−52.8–60.1]% vs. 70.1 [−14.5–214.2]%, P=0.004), while the changes in MMP-2 were not significantly different between the two groups during the study period.