학술논문
Osteoporotic Pain is Associated with Increased Transient Receptor Vanilloid 4 Expression in the Dorsal Root Ganglia of Ovariectomized Osteoporotic Rats: A Pilot Basic Study
Document Type
Journal Article
Author
Hideyuki Kinoshita; Hirohito Kanamoto; Junichi Nakamura; Kazuhide Inage; Kazuhisa Takahashi; Kazuki Fujimoto; Kazuyo Yamauchi; Koki Abe; Masahiro Inoue; Masaki Norimoto; Masao Koda; Miyako Suzuki; Seiji Ohtori; Shigeo Hagiwara; Sumihisa Orita; Takeo Furuya; Tomotaka Umimura; Tsutomu Akazawa; Yasuchika Aoki; Yasuhiro Shiga; Yawara Eguchi; Yusuke Matsuura
Source
Spine Surgery and Related Research. 2018, 2(3):230
Subject
Language
English
ISSN
2432-261X
Abstract
Results: There was no statistical difference in the number of FluoroGold-positive DRG neurons between groups; however, there were significantly more CGRP-ir/TRPV4-ir FluoroGold-positive DRG neurons in the OVX group compared with the sham control group (P < 0.05) as well as the significantly increased molecular production of each peptide. Intravertebral pH was also lower in the OVX group compared with the sham control group (P < 0.05).