학술논문
Electrospun nanofibrous scaffold made from PHA copolymers: fabrication, physical characterization, tissue response and in vitro biodegradation
Document Type
Journal Article
Author
Source
Polymer Preprints, Japan. 2007, :2269
Subject
Language
English
Abstract
In this study, poly(3-hydroxybutyrate-co-5mol%-3-hydroxyhexanoate) [P(3HB-co-5mol%-3HHx)], poly(3-hydroxybutyrate-co-7mol%-4-hydroxybutyrate)and poly(3-hydroxybutyrate-co-97mol%-4-hydroxybutyrate) were electrospun in aim of fabricating scaffolds with enhanced biocompatibility, mechanical properties and bioabsorption. X-ray diffraction revealed that P(3HB-co-5mol%-3HHx) is highly crystalline, thus showing the highest Young's Modulus but slowest bioabsorption rate. Interestingly, the mechanical properties of all as-spun nanofibers were found to be comparable to those of human skin. This study demonstrated that high 4HB content facilitates rapid bioabsorption and elicits minimal tissue inflammation in vivo.