학술논문
Phase III study results of Lomefloxaciin (NY-198) otic solution for the treatment of chronic purulent otitis media and its acute exacerbations / 慢性化膿性中耳炎および慢性化膿性中耳炎急性増悪症に対するLomefloxacin (NY-198) 耳用液の臨床第III相比較試験成績
Document Type
Journal Article
Author
Akihiko TAKASU; Akio SUZUKI; Akira TONAI; Ginichiro ICHIKAWA; Goro MOGI; Haruji KINOSHITA; Hideyo ASAI; Hideyuki KAWAUCHI; Hirofumi MATSUYAMA; Hirokazu KAWANO; Hiroshi WATANABE; Hitoshi OGINO; Hitoshi SAITO; Ichiho MORIBE; Isao TAKIMOTO; Jun HONDO; Junichi BUNDO; Katsuhiro HIRAKAWA; Kazuaki OGAWA; Kazuhiko GOTO; Kazuhiko TAKEUCHI; Ken ARIKI; Kiichi SATO; Kiyo KANO; Koichi DEGUCHI; Koichi KITA; Koichi YAMASHITA; Koji YAJIN; Kotaro UKAI; Kozo FUKAMI; Makoto SHIRANE; Masao NAITO; Masao YASUDA; Masaru OYAMA; Mikiko TAKAYAMA; Mikio YAGISAWA; Minako YAMAMOTO; Mitsuhiro SANO; Mitsuru FURUKAWA; Mitsuyoshi NAKASHIMA; Nagahiro So; Nobuo TAKASUKA; Noriko OKADA; Ryozo UMEDA; Satoaki Hojo; Shigenobu IWATA; Shigeru INAFUKU; Shinji KATO; Shinjiro ONISHI; Shozo KAWAMURA; Shubun TAKEBAYASHI; Shunkich BABA; Sugata TAKAHASHI; Tadao NISHIMURA; Takashi KAWAI; Takatsugu ITABASHI; Takehiro KOBAYASHI; Takehisa SAITO; Takeshi MARUO; Tamotsu MORIMITSU; Tatsuya TAKIGUCHI; Teruhisa NOIRI; Tetsuji HORI; Tetsuo ISHII; Tetsuya SHIMA; Toru KITAGAKI; Toru MATSUNAGA; Toshitada SAKAI; Toshiyuki MIYOSHI; Tsuneharu HIROTA; Yasuo HARADA; Yasuo SAKAKURA; Yayoi SATO; Yoriko ITO; Yuichi NAKANO; Yuko NINOMIYA; Yutaka SAKAMOTO; 三好 敏之; 中島 光好; 中野 雄一; 丸尾 猛; 二宮 優子; 伊藤 依子; 佐藤 喜一; 佐藤 弥生; 佐野 光仁; 八木澤 幹夫; 内藤 雅夫; 出口 浩一; 分藤 準一; 加藤 眞二; 北垣 徹; 北條 郷明; 原田 康夫; 古川 仭; 坂倉 康夫; 坂本 裕; 堀 哲二; 夜陣 紘治; 大山 勝; 大西 信治郎; 安田 誠夫; 宗 永浩; 小川 和明; 小林 武弘; 山下 公一; 山本 美奈子; 岡田 能理子; 岩田 重信; 島 哲也; 川内 秀之; 市川 銀一郎; 平川 勝洋; 廣田 常治; 後藤 和彦; 斎藤 武久; 有木 健; 木下 治二; 本堂 潤; 東内 朗; 松山 博文; 松永 亨; 板橋 隆嗣; 梅田 良三; 森満 保; 森部 一穂; 河合 峯; 河村 正三; 河野 浩万; 浅井 英世; 深水 浩三; 渡辺 洋; 瀧口 哲也; 瀧本 勲; 狩野 秀代; 白根 誠; 石井 哲夫; 稲福 繁; 竹内 万彦; 竹林 脩文; 紀太 康一; 茂木 五郎; 荻野 仁; 西村 忠郎; 酒井 利忠; 野入 輝久; 鈴木 昭男; 馬場 駿吉; 高山 幹子; 高橋 姿; 高須 昭彦; 高須賀 信夫; 鵜飼 幸太郎; 齋藤 等
Source
耳鼻と臨床 / jibi to rinsho. 1991, 37(1):78
Subject
Language
Japanese
ISSN
0447-7227
2185-1034
2185-1034
Abstract
The efficacy, s afety and utility of lomefloxacin (NY-198) otic solution in chronic suppurative otitis media were evaluated by a well-controllecd omparative study using cefmenoxime (CMX) otic solution as a control.(1) Clinical effect: Whether based on the doctor's evaluation or the committee evaluation, no significandt difference was found between the NY-198 group and the CMXg roup. However, according to the doctor's evaluation, the NY-198 group tended to be superior in moderate cases.(2) Bacteriological effect: The NY-198 group tended to be superior in the elimination (%) of P. aeruginosa and was significantly more effective against gram-negative bacteria as a whole.(3) Side effects:Whereas side effects developed in 2 cases (2.0%) in the CMX group, no side effects were found in the NY-198 group.(4) Utility: The NY-198 group tended to be superior. Based on the above results, it was concluded that NY-198 otic solution would be a highly effective, safe and useful topical therapy for chronic suppurative otitis media.