부산대학교 도서관

Since 1977 mass screening for breast cancer has been conducted in Miyagi prefecture, Japan ; inspection, palpation and cytologic examination of any nipple discharge are part of the initial screening procedures. Nipple discharge cytology was performed on 61, 421 subjects (10.8% of the total). The cytologic diagnosis was positive in 54 subjects, cancer could not be ruled out in 85, epithelial hyperplasia in 1, 386, atypical findings in 7, 409 and no atypical finding in 52, 493. Discharge cytology in 626 cases (190 cancers and 436 benign) histologically identified had 20.5% sensitivity, 91.1% specificity, 69.7% accuracy, 50.0% positive predictive value and 72.5% negative predictive value if “cancer not ruled out” was classified as an error in both cancer and benign cases.Discharge cytology was useful for detection of non-invasive and/or nonpalpable breast cancers and epithelial hyperplasia.