학술논문
A next generation therapy to treat obesity through thebrain / A next generation therapy to treat obesity throughthe brain
Document Type
Journal Article
Author
Alzina Sara; Ana Cristina Reguera; Anna Fosch Paraiso; Ariza Xavier; Casals Núria; Dolors Serra; Fukushima Shigeto; Garcia Jordi; Garcia-Chica Jesús; Herrero Laura; Jesús Garcia-Chica; Jordi Garcia; Kataoka Kazunori; Kazuko Toh; Kazunori Kataoka; Kristian D. West; Laura Herrero; Laura Sánchez-García; Núria Casals; Paraiso Anna Fosch; Quader Sabina; Reguera Ana Cristina; Rodríguez-Rodríguez Rosalía; Rosalía Rodríguez-Rodríguez; Sabina Quader; Sara Alzina; Sebastian Zagmutt; Serra Dolors; Shigeto Fukushima; Sánchez-García Laura; Toh Kazuko; West Kristian D.; Xavier Ariza; Zagmutt Sebastian
Source
Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2023, :2-064
Subject
Language
Japanese
ISSN
2435-4953
Abstract
Obesity has become an important health problem and its prevalence is highlyincreasing. Pharmacotherapy alone or in combination with either lifestylemodification or surgery, is consistent in maintaining a healthy body weight, andpreventing progression to obesity-related diseases. However, the anti-obesitydrugs are limited by non-specificity and unsustainable weight loss effects.Therefore, further research is needed to develop new preventive and treatmentapproaches against obesity. Here we targeted the brain lipid metabolism as apromising strategy. In the brain,the hypothalamus harbors specialized functional circuits in thephysiological regulation of calories intake and spend. Importantly, some enzymesinvolved in fatty acid metabolism are highly expressed in the hypothalamus. Wetook advantage of the C75-CoA, a strong competitive inhibitor of carnitinepalmitoyltransferase 1A (CPT1A) that catalyzes the rate-limiting step offatty-acid oxidation.