학술논문
Acetamideの肝発がん機序に関する検討: 血液及び肝臓中動態のラット系統差の比較 / Investigations of the mechanisms of acetamide-induced hepatocarcinogenesis – Comparison of rat strain differences in AA toxicokinetic
Document Type
Journal Article
Author
Source
Annual Meeting of the Japanese Society of Toxicology. 2022, :P-161
Subject
Language
Japanese
Abstract
[Results] In both strains, plasma AA concentration reached Cmax at 4 hr after oral administration and at 0.5 hr after intravenous administration, and then decreased. No strain differences were observed in Cmax and T1/2. AA concentrations in the liver correspond to that in the plasma, and had no differences between strains. Histopathologically, the number of binuclear hepatocytes with irregularly shaped smaller nuclei increased in the liver of F344 rats at 24 hr rather than that of Wistar rats.