학술논문
Population-Based Impact of Smoking, Drinking, and Genetic Factors on HDL-cholesterol Levels in J-MICC Study Participants
Document Type
Journal Article
Author
Asahi Hishida; Daisaku Nishimoto; Etsuko Ozaki; Haruo Mikami; Hidemi Ito; Hiroaki Ikezaki; Ippei Shimoshikiryo; Keiichi Shimatani; Keitaro Matsuo; Kenji Takeuchi; Kenji Wakai; Kiyonori Kuriki; Kokichi Arisawa; Mako Nagayoshi; Masahiro Nakatochi; Masayuki Murata; Megumi Hara; Michiaki Kubo; Naoko Miyagawa; Naoyuki Takashima; Rie Ibusuki; Rieko Okada; Sadao Suzuki; Sakurako Katsuura-Kamano; Takahiro Otani; Takashi Tamura; Teruhide Koyama; Toshiro Takezaki; Yohko Nakamura; Yora Nindita; Yuichiro Nishida; Yukihide Momozawa
Source
Journal of Epidemiology. 2023, 33(4):193
Subject
Language
English
ISSN
0917-5040
1349-9092
1349-9092
Abstract
Results: We found that smoking, drinking, daily activity, habitual exercise, egg intake, BMI, age, sex, and the SNPs CETP rs3764261, APOA5 rs662799, LIPC rs1800588, LPL rs328, ABCA1 rs2575876, LIPG rs3786247, and APOE rs429358 were associated with HDL-C levels. The gene-environmental interactions on smoking and drinking were not statistically significant. The PAF for low HDL-C was the highest in men (63.2%) and in rs3764261 (31.5%) of the genetic factors, and the PAFs of smoking and drinking were 23.1% and 41.8%, respectively.