학술논문
Mendelian Randomization Study Does Not Support a Bidirectional Link between Atherosclerosis and Venous Thromboembolism
Document Type
Journal Article
Author
Source
Journal of Atherosclerosis and Thrombosis. 2023, 30(9):1265
Subject
Language
English
ISSN
1340-3478
1880-3873
1880-3873
Abstract
Results: The genetically instrumented VTE (odds ratio [OR]: 1.05; 95% confidence interval [CI]: 1.00–1.11; P=0.06), DVT (OR: 1.03; 95% CI: 0.99–1.08; P=0.19), or PE (OR: 1.07; 95% CI: 0.98–1.16; P=0.11) showed no causal relationships with CHD. There was also no clear evidence showing the causal effects of CHD on VTE (OR: 1.00; 95% CI: 0.82–1.22; P=0.98), DVT (OR: 1.00; 95% CI: 0.79–1.27; P=0.97), or PE (OR: 0.98; 95% CI: 0.82–1.18; P=0.87). No pleiotropic bias was found in the MR analyses. As heterogeneity was significant, a random model was used to minimize the effect of heterogeneity.