학술논문
CISH is a negative regulator of IL-13-induced CCL26 production in lung fibroblasts
Document Type
Journal Article
Author
Source
Allergology International. 2019, 68(1):101
Subject
Language
English
ISSN
1323-8930
1440-1592
1440-1592
Abstract
Results: Ingenuity pathway analysis revealed that IL-13 induced chemokine signaling, including the eotaxin family, while significantly suppressing IFN-α/β signaling. Among eight SOCS family members, CISH was most strongly induced by IL-13 via phosphorylation of signal transducer and activator of transcription 6 (STAT6). Loss- and gain-of-function studies demonstrated that CISH negatively regulated the expression of CCL26.