학술논문
Unusual Skin Reactions after Mosquito Bites and Epstein-Barr Virus Reactivation in a Patient with Mantle Cell Lymphoma
Document Type
Journal Article
Author
Source
Internal Medicine. 2004, 43(10):986
Subject
Language
English
ISSN
0918-2918
1349-7235
1349-7235
Abstract
We detected Epstein-Barr virus (EBV) reactivation in a patient with mantle cell lymphoma (MCL). The patient, a 53-year-old Japanese man, had been referred to our hospital because of generalized lymphadenopathy, hepatosplenomegaly and lymphocytosis and gave a history of intense skin reactions to mosquito bites. The biopsied lymph node contained a monotonous proliferation of medium-sized lymphocytes with scant cytoplasm and slightly irregular nuclei that were CD5+, CD20+ and CD23-. Antibody titers of IgG against EBV viral capsid antigen and early antigen were increased, and EBV was detected in the lymphoma cells. This case may suggest a relationship between EBV and MCL.