부산대학교 도서관

Using the asthograph, we investigated the effect of ketotifen on the hyperresponsiveness of the nasal mucosa in 12 patients with allergic rhinitis.Ketotifen was administered (2mg a day in two doses) for eight weeks.Inhalation tests of methacholine through the nose were performed with the asthograph before and after the course of medication, and eosinophil counts were recorded.i) There was no significant change in initial nasal respiratory resistance (Rrs. N. cont).ii) Hypersensitivity of the nasal mucosa reflected by Dmin decreased significantly after eight weeks of treatment.iii) Nasal reactivity reflected by Sd. N did not change significantly during treatment.iv) Eosinophil counts in nasal secretions and blood did not change significantly.