학술논문
CD20陽性多発性骨髄腫は成熟小型細胞で11;14転座が関連する / Close correlations between CD20 expression, a small mature plasma cell morphology and t(11;14) in multiple myeloma
Document Type
Journal Article
Author
Source
臨床血液 / Rinsho Ketsueki. 2005, 46(12):1293
Subject
Language
Japanese
ISSN
0485-1439
1882-0824
1882-0824
Abstract
Stratification of patients with multiple myeloma (MM) may be important. We investigated 138 MM patients, focusing on correlations between CD20 expression, 11;14 translocation, morphology of MM cells, cyclin D1 immunostaining, and the prognosis. About 15% of patients (7/47 cases) were CD20-positive, small mature MM cells, with positive cyclin D1 in the nucleus and 11;14 translocation. Two color analysis of CD38×CD20 antigens may be necessary to investigate CD20 expression on MM cells. Rituximab may be effective for the treatment of CD20-positive MM.