학술논문
Effects of Chlorpromazine on Serum GPT Activity and Drug-Metabolizing Enzyme Activity in the Rat with Hepatic Injury / 肝障害ラットの血清GPT値および肝薬物代謝酵素に及ぼすクロルプロマジンの影響
Document Type
Journal Article
Author
Source
病院薬学 / Japanese Journal of Hospital Pharmacy. 1991, 17(5):330
Subject
Language
Japanese
ISSN
0389-9098
2185-9477
2185-9477
Abstract
Effects of chlorpromazine (CPZ) on serum GPT (SGPT) and hepatic microsomal drug-metabolizing enzyme activities in the rat with liver injured by CCl4 were studied.Rats were intraperitoneally injected with CCl4 at a dose of 0.2ml/kg every 3 days, and with CPZ at a dose of 5 mg/kg once a day for 48 days. SGPT activity was gradually elevated from the beginning of CCl4-administration and reached to the maximum after 30 days.The elevation of SGPT value induced by CCl4-administration was inhibited by the administration of CPZ.In addition, decreases of cytochrome P-450 and cytochrome b5 by CCl4-administration were observed.However, CPZ restored the decrease of cytochrome P-450.These results indicate that CPZ protects liver cell damage induced by CCl4, resulting in that the effect of CPZ on cytochrome P-450 may be important for protecting from drug-induced hepatic injury.