부산대학교 도서관

We studied periodontal tissue regeneration following application of platelet-rich plasma (PRP) on monkey buccal dehiscence defects. Buccal dehiscence defects were surgically created on both sides of the maxillary first and second premolars of four monkeys. PRP was derived from the blood of each animal, and atelocollagen was used as a carrier. The periodontal defects on the left side were filled with atelocollagen containing PRP (PRP group) and those on the right with only atelocollagen (control group). Histological analysis and histomorphometric measurements were then performed on the euthanized monkeys 6 and 12 weeks after surgery. The rates of bone regeneration and new cementum formation were greater in PRP group than in the controls at all observation periods. Apical migration of the junctional epithelium was lower in the PRP group than in the controls, and the new cementum of the PRP group contained cementocytes. The results suggest that implanting PRP in periodontal defects has a significant effect on the promotion of bone regeneration and new cementum formation. However, the new cementum was reparative cementum.