학술논문
Neurocognitive performance of Japanese children with acute lymphoblastic leukemia: a prospective longitudinal study / 小児急性リンパ性白血病患児における認知機能の前方視的多施設協同研究
Document Type
Journal Article
Author
Akira Hayakawa; Arata Watanabe; Atsushi Sato; Hirokazu Kanegane; Hitoshi Dairoku; Junko Takita; Katsuyoshi Koh; Keiko Nomura; Kimikazu Matsumoto; Miho Kato; Motoaki Chin; Satomi Sato; Setsuo Ota; Shosuke Sunami; Takashi Fukushima; Takashi Taga; Tetsuya Takimoto; Toshinari Hori; Yoshiyuki Kosaka; Yuichi Taneyama; Yuki Yuza; 佐藤 篤; 佐藤 聡美; 加藤 実穂; 堀 壽成; 多賀 崇; 大六 一志; 太田 節雄; 小阪 嘉之; 康 勝好; 早川 晶; 松本 公一; 渡辺 新; 湯坐 有希; 滝田 順子; 瀧本 哲也; 福島 敬; 種山 雄一; 角南 勝介; 野村 恵子; 金兼 弘和; 陳 基明
Source
日本小児血液・がん学会雑誌 / The Japanese Journal of Pediatric Hematology / Oncology. 2021, 58(5):424
Subject
Language
Japanese
ISSN
2187-011X
2189-5384
2189-5384
Abstract
High-dose intravenous methotrexate (HD-MTX) and intrathecal MTX can cause long-term neurotoxicity that adversely affects intellectual function. We report the final results of a three-year longitudinal study of cognitive function of patients from 23 institutions. Data were collected from children diagnosed as having standard-risk acute lymphoblastic leukemia (ALL) between 2011 and 2016. A total of 57 patients aged three to nine years at the time of diagnosis were consecutively enrolled and the results of 43 were statistically analyzed. We used the Wechsler Intelligence Scale for Children-4th Edition (WISC-IV) to obtain the scores for full-scale IQ (FSIQ), verbal comprehension index (VCI), perceptual reasoning index (PRI), working memory index (WMI), and processing speed index (PSI). The cognitive function of participants was tested using WISC-IV before and three times after the completion of HD-MTX therapy over three years. The four indices (VCI, PRI, WMI, and PSI) were statistically compared across four time points using ANOVA. Mean FSIQ scores were 99.09 (SD=14.72), 99.26 (SD=15.01), 102.30 (SD=11.08), and 101.12 (SD=11.69) at the four time points, respectively. Scores of Verbal Comprehension at TIME 1 were the lowest, whereas those of Working Memory were the lowest after TIME 2. These results should be verified with respect to daily life problems encountered by the patients.