학술논문
93 Structures of Cytotoxic Substances and New Quinazoline Derivatives Produced by a Fungus from a Saltwater Fish / 93 海水魚由来の真菌の産生する細胞毒性物質および新規キナゾリン誘導体の構造(口頭発表の部)
Document Type
Journal Article
Author
Source
Symposium on the Chemistry of Natural Products, symposium papers. 1991, :723
Subject
Language
Japanese
ISSN
2433-1856
Abstract
Fifteen metabolites were isolated from the mycelium and culture filtrate of a strain of Aspergillus fumigatus which existed in the gastrointestinal tract of the saltwater fish Pseudolabrus japonicus. Among them, TR-2, fumitremorgin C and gliotoxin exhibited significant cytotoxicity against the cultured P-388 lymphocytic leukemia cells. Analysis of long range ^1H-^<13>C COSY and other spectral data for the five new metabolites[FQ-A(1),-B(2),-C(3),-D(4)and -E(5)], exhibiting marginal or moderate cytotoxicity, allowed assignment of their structures containing quinazolone and indoline moieties. The absolute stereostructure of 3 was determined on the basis of X-ray crystallographic analysis as well as of the production of L-(+)-alanine by its acidic hydroloysis. The stereochemistry of the other metabolites was established by deriving 1 and 5, from 3 and other chemical behavior.