부산대학교 도서관

Objective: To examine the causes of sequelae or death of patients who presented them subsequently to seizures that developed during theophylline administration. Methods: Among 334 patients who had been examined in Study (I), we wxtracted 56 who had sequelae or died subsequently to the onset of seizures and examined their causes. Results: Many patients had fever at the onset of seizures, many patients had neurologic predispositions prior to seizure onset, and only one patient was found to be free from fever and neurologic findings. At the onset of seizures, most of these patients had blood theophylline concentrations that were within or inferior to the target range (5-15μg/mL). Conclusions: We presume it necessary to pay heed to fever and neurologic predispositions in order to prevent sequelae or death that may occur subsequently to seizures that developed during theophylline administration.