학술논문
Electrocardiographic Diagnosis of Hypertrophic Cardiomyopathy in the Pre- and Post-Diagnostic Phases in Children and Adolescents
Document Type
Journal Article
Author
Akiko Komori; Daisuke Hazeki; Eiki Nishihara; Fukiko Ichida; Fumie Takechi; Hideto Takahashi; Hiromitsu Ogata; Hiroya Ushinohama; Hiroyuki Tsutsui; Hitoshi Horigome; Katsumi Abe; Kazushi Yasuda; Keiichi Hirono; Kentaro Ueno; Kunio Ohta; Mamoru Ayusawa; Mari Iwamoto; Masahiro Sonoda; Masami Nagashima; Masao Yoshinaga; Minoru Horie; Naokata Sumitomo; Naomasa Makita; Naomi Izumida; Nobuo Tauchi; Norihito Nuruki; Satoru Kawai; Seiichi Sato; Seiko Ohno; Shigetoyo Kogaki; Shouji Matsushima; Shozaburo Doi; Sigeru Tateno; Susumu Hosokawa; Tadayoshi Hata; Taichi Kato; Takashi Higaki; Tatsunori Hokosaki; Tatsuya Yoneyama; Toshiyuki Chisaka; Yoshiaki Kato; Yoshihiro Nozaki; Yuichi Ishikawa; Yuichi Nomura; Yuji Tanaka; Yumiko Ninomiya
Source
Circulation Journal. 2021, 86(1):118
Subject
Language
English
ISSN
1346-9843
1347-4820
1347-4820
Abstract
Methods and Results:ECGs at the 1st grade (mean [±SD] age 6.6±0.3 years) were available for 11 patients diagnosed with HCM at around the 7th grade (13.2±0.3 years). ECGs were available for another 64 patients diagnosed with HCM in the 1st (n=15), 7th (n=32), and 10th (n=17) grades. Fifty-one voltage criteria were developed by grade and sex using 62,841 ECGs from the general population. Voltage criteria were set at the 99.95th percentile (1/2,000) point based on the estimated prevalence of childhood HCM (2.9 per 100,000 [1/34,483]) to decrease false negatives. Conventional criteria were from guidelines for school-aged children in Japan. Of 11 patients before diagnosis, 2 satisfied conventional criteria in 1st grade; 5 (56%) of the remaining 9 patients fulfilled 2 voltage criteria (R wave in limb-lead I [RI]+S wave in lead V3 [SV3] and R wave in lead V3 [RV3]+SV3). Robustness analysis for sensitivity showed RV3+SV3 was superior to RI+SV3. For all patients after diagnosis, RI+SV4 was the main candidate. However, conventional criteria were more useful than voltage criteria.