학술논문
A case of advanced hepatocellular carcinoma with hepatitis C virus infection treated effectively with Peg-IFNα2a / ペグインターフェロンα-2a単独投与を含む集学的治療が奏功したC型肝炎合併進行肝細胞癌の1例
Document Type
Journal Article
Author
Atsunori Onishi; Daisuke Takiuchi; Hidetaka Yasuoka; Hiroshi Ohashi; Junya Okabe; Kazuto Fukuda; Kunitaka Shibata; Mai Yagi; Masanori Nakahara; Mizuki Tani; Osakuni Morimoto; Sachiyo Kogita; Shinichiro Zushi; Takayuki Iwamoto; Takumi Igura; Taro Marukawa; Yasuharu Imai; Yasushi Matsumoto; Yoshiyuki Sawai; Yosuke Yamagata; 中原 征則; 丸川 太朗; 井倉 技; 今井 康陽; 八木 麻衣; 厨子 慎一郎; 大橋 寛嗣; 大西 孝典; 安岡 秀高; 小来田 幸世; 山縣 洋介; 岡部 純弥; 岩本 剛幸; 松本 康史; 柴田 邦隆; 森本 修邦; 澤井 良之; 瀧内 大輔; 福田 和人; 谷 瑞季
Source
肝臓 / Kanzo. 2015, 56(6):280
Subject
Language
Japanese
ISSN
0451-4203
1881-3593
1881-3593
Abstract
A 59-year-old man with hepatitis C virus infection who had undergone micro wave coagulation therapy for 2 cm of hepatocellular carcinoma (HCC) in 2004 developed multiple recurrence in January 2011 and referred to our hospital. In spite of hepatic artery chemo embolization therapy, sorafenib, hepatic arterial infusion chemotherapy, and oral S-1, the tumors increased in size and number. Serum AFP and PIVKA II levels were also elevated. After administration of 180 μg of Peg-INFα-2a every week, the levels of AFP and PIVKA II had markedly decreased. Eleven months after the initiation of 180 μg of Peg-INFα-2a treatment, the multiple hepatic tumors and lung metastases which were observed during the course disappeared. Although the recurrence of S3 appeared afterward, lobectomy of left lobe segment was successfully performed, resulting in normalization of serum AFP and PIVKAII. Peg-IFNα-2a might be a possible therapeutic option for advanced HCC.