부산대학교 도서관

A 74 year-old man, who was suffering from glaucoma, was treated with four ophthalmic drugs. As intraocular pressure increased despite treatment, Glanatec® ophthalmic solution was prescribed in addition to the four drugs. One year later, physical examination revealed erythema and edema of the upper and lower eyelids, and erythema from the inner canthus to the nasolabial fold. Since contact dermatitis was suspected, the patient was admitted to our hospital. We performed patch and scratch patch testing for all five ophthalmic drugs. Only the Glanatec® ophthalmic solution showed a positive reaction. After Glanatec® ophthalmic solution was discontinued, the symptoms rapidly subsided. To further investigate, we performed patch and scratch patch testing for the ingredients of Glanatec® ophthalmic solution. Only ripasudil hydrochloride hydrate, which is the active ingredient, showed a positive reaction. The patient was diagnosed as having contact dermatitis due to ripasudil hydrochloride hydrate contained in Glanatec® ophthalmic solution.