부산대학교 도서관

In order to obtain synthetic high polymer enteric coating agent, various copolymers of methyl acrylate, acrylic acid, methyl methacrylate, and methacrylic acid were synthesized. These polymers were examined for their solubility in simulated gastric and enteric juice, permeability of water vapor through the film, and their viscosity and disintegrability were measured. Their availability as enteric coating agent was also examined and comparative examinations were made with shellac and cellulose acetate phthalate. It was thereby found that excellent enteric coating agent is found in methyl acrylate-acrylic acid system containing 9-42 molar % of free acid, methyl methacrylate-methacrylic acid system with around 70 molar % of free acid, and methyl acrylate-methacrylic acid system with 19-52 molar % of free acid. These polymers were also found to have better water vapor permeabilty and disintegrability than shellac or cellulose acetate phthalate.