학술논문
A Well-Contorolled Comparative Study on Ceftriaxone with Cefotaxime in Respiratory Tract Infections / 呼吸器感染症に対するセフトリアキソンとセフォタキシムの薬効比較試験
Document Type
Journal Article
Author
Akihiko KUZE; Akio ONAKA; Akira SAITO; Akira SUZUKI; Akira WATANABE; Atsushi SAITO; Chiharu KUBO; Eiji INOUE; Eiro TSUBURA; Fukuo IJIMA; Fumio MIKI; Fumio NAGAHAMA; Fusanosuke YAMASAKU; Hideo IKEMOTO; Hideo SASAKI; Hirofumi FUKUHARA; Hiroichi TANIMOTO; Hiromaru IWASAKI; Hiroshi KON; Hiroshi OKUBO; Hiroshi OSHITANI; Hirotada IKEDA; Hiroyoshi ISHIBASHI; Hiroyuki KOBAYASHI; Hiroyuki KUMANO; Hisashi NAKAHATA; Hitoshi NAGANO; Ichiro NAKAYAMA; Ippei FUJIMORI; Izumi HAYASHI; Jingoro SHIMADA; Jun GOTO; Junzaburo KABE; Jutaro SHIMOMURA; Kaneo SUZUKI; Kaoru OKADA; Kaoru OYAMA; Kaoru SHIMADA; Katsuo SUZUKI; Kazufuto FUKAYA; Kazuo SAKAMOTO; Kazuo SASAKI; Kazuo TAKEBE; Kazuyoshi WATANABE; Keigo MAEHARA; Keiichi NAKAGAWA; Keijyu LEE; Keimei MASHIMO; Keizo MATSUMOTO; Keizo YAMAGUCHI; Kenji TAKAMURA; Kentaro WATANABE; Kikuo ONUMA; Kiyofumi ISHIKAWA; Kiyohito TAKAHASHI; Kiyoshi KONNO; Kohei HARA; Kohtaro ITAKURA; Koichiro NAKATA; Kotaro OIZUMI; Kouichi WADA; Kouu MUROHASHI; Koya SHIBA; Kunihiko YOSHIMURA; Kyoko URAYAMA; Makoto NAKAZONO; Masaaki ARAKAWA; Masahiro TSUTSUI; Masahito KATO; Masakazu TAMURA; Masako SASAKI; Masanobu KAJI; Masao TAMURA; Masaru KOYAMA; Masaru NAKAGAWA; Masaru NASU; Masataka KATSU; Masumi TOMIZAWA; Michiyasu NAKANISHI; Mikio TAGUCHI; Minoru YOSHIYAMA; Mitsuharu OGI; Mitsuo MASUDA; Mitsuo SUZUKI; Morikuni ABE; Morio SAGARA; Naohiko CHONABAYASHI; Nobuki AOKI; Nobuo MAEKAWA; Osamu KURIMURA; Osamu SEKINE; Reiko SASAKI; Rensuke KURODA; Rinzo SOEJIMA; Seibun YONEZU; Seiichi AONUMA; Seiichi MURAKAMI; Seiichi OHHIRA; Shigeki ODAGIRI; Shinichi TANIZAWA; Shinya YASUDA; Shiroh IDA; Shirou KOSAKA; Shunichi MAEDA; Shuzaburo FUKUYAMA; Sumio YAMAOKA; Tadashi MIYAHARA; Takashi INAMATSU; Takashi ITO; Takashi ITOGA; Takayoshi TASHIRO; Takehisa MURAKAMI; Takehisa YAMAJI; Tamotsu KANEKO; Tamotsu TAKISHIMA; Tatsuo NAKATANI; Tetsuto MURATA; Tomoko NIHEI; Toshiaki HAYASHI; Toshihiko TAKEUCHI; Toshio HOJO; Toshiyuki OYE; Toshiyuki YAMAMOTO; Tuyoshi KIKUIRI; Yasutoshi SUZUKI; Yasuyuki SANO; Yoichiro GOTO; Yoji SUZUYAMA; Yomei HIRAGA; Yoshihiko KURODA; Yoshihiro UEDA; Yoshiji YAMANE; Yoshimaru USUDA; Yoshio KOBAYASHI; Yoshio KURIHARA; Yoshiro SAWAE; Yoshitaka NAKAMORI; Yoshiteru SHIGENO; Yoshito NIKI; Yoshiyasu IKUNO; Yube IIDA; Yujiro SUZUKI; Yukio KUMAGAI; Yukio NOGUCHI; Yuruko OKAMOTO; Yuzo MORI; 三木 文雄; 上田 良弘; 下村 壽太郎; 中園 誠; 中山 一朗; 中川 勝; 中川 圭一; 中森 祥隆; 中田 紘一郎; 中畑 久; 中西 通泰; 中谷 龍王; 久世 彰彦; 久保 千春; 二木 芳人; 二瓶 倫子; 井上 英二; 井田 士朗; 今 寛; 今野 淳; 伊藤 隆司; 佐々木 和雄; 佐々木 昌子; 佐々木 玲子; 佐々木 英夫; 佐野 靖之; 前原 敬悟; 前川 暢夫; 前田 俊一; 副島 林造; 加地 正伸; 加藤 政仁; 勝 正孝; 北條 敏夫; 原 耕平; 可部 順三郎; 吉村 邦彦; 和田 光一; 坂元 一夫; 増田 光男; 大久保 滉; 大山 馨; 大平 誠一; 大沼 菊夫; 大泉 耕太郎; 安田 悳也; 室橋 光宇; 宮原 正; 富沢 磨須美; 小坂 志郎; 小山 優; 小林 宏行; 小林 芳夫; 小江 俊行; 小田切 繁樹; 尾仲 章男; 山作 房之輔; 山口 恵三; 山岡 澄夫; 山本 俊幸; 山根 至二; 山路 武久; 岡本 緩子; 岡田 薫; 岩崎 博圓; 島田 馨; 嶋田 甚五郎; 平賀 洋明; 後藤 純; 後藤 陽一郎; 押谷 博; 斉藤 篤; 斎藤 厚; 斎藤 玲; 李 啓充; 村上 剛久; 村上 誠一; 村田 哲人; 松本 慶蔵; 板倉 康太郎; 林 敏明; 林 泉; 柴 孝也; 栗原 義夫; 栗村 統; 武内 俊彦; 武部 和夫; 池本 秀雄; 池田 大忠; 浦山 京子; 深谷 一太; 渡辺 一功; 渡辺 健太郎; 渡辺 彰; 澤江 義郎; 瀧島 任; 熊谷 幸雄; 熊野 博之; 生野 善康; 田代 隆良; 田口 幹雄; 田村 昌士; 田村 正和; 盛 勇造; 相楽 衛男; 真下 啓明; 石川 清文; 石橋 弘義; 福原 弘文; 福山 周三郎; 稲松 孝思; 筒井 理裕; 米津 精文; 糸賀 敬; 荒川 正昭; 菊入 剛; 萩 光春; 葭山 稔; 薄田 芳丸; 藤森 一平; 蝶名林 直彦; 螺良 英郎; 谷本 普一; 谷澤 伸一; 那須 勝; 重野 芳輝; 野口 行雄; 金子 保; 鈴山 洋司; 鈴木 克男; 鈴木 周雄; 鈴木 密雄; 鈴木 康稔; 鈴木 明; 鈴木 雄二郎; 長浜 文雄; 長野 準; 関根 理; 阿部 守邦; 青木 信樹; 青沼 清一; 飯島 福生; 飯田 夕; 高村 研二; 高橋 清仁; 黒田 練介; 黒田 義彦
Source
感染症学雑誌 / Kansenshogaku Zasshi. 1986, 60(2):102
Subject
Language
Japanese
ISSN
0387-5911
1884-569X
1884-569X
Abstract
For the purpose of evaluating the efficacy, safety and usefulness of ceftriaxone (CTRX), a cephem antibiotic, in respiratory tract infections, a well-controlled comparative study was carried out with cefotaxime (CTX) for a reference.One (1) gm of either CTRX or CTX was administered by drip infusion twice a day for 7 to 14 days in principle into patients with chronic bronchitis and diffuse panbronchiolitis aggravated with infections, chronic respiratory diseases accompanied with infections in the lower respiratory tract like bronchiectasis, bronchial asthma, pulmonary emphysema, pulmonary fibrosis, obsolete pulmonary tuberculosis, lung cancer, etc. and bacterial pneumonia.Results were as follows:1) Clinical efficacy: The efficacy rate was 81%(100/124) with CTRX and 74%(94/127) with CTX, with no statistically significant difference between the two drugs. The efficacy rate in the moderately infected patients was 81%(54/67) with CTRX and 62%(37/60) with CTX, CTRX being significantly superior to CTX.If cases infected with P. aerugirrosa were excluded, CTRX was higher in efficacy than CTX.2) Bacteriological effects: The bacterial eradication occurred in 35 patients out of 44 (80%) with CTRX and in 42 out of 54 (78%) with CTX, with no statistically significant difference. There was no significant difference in efficacy between the two, whether according to strains of isolates or types of infections (single or mixed).3) Adverse reactions: The incidence of adverse reactions was 10.5%(14/133) to CTRX and 6.3%(9/143) to CTX, no statistically significant difference being noticed. The incidence of skin rash was significantly higher with CTRX. In the clinical laboratory test, abnormal signs were observed in 37 out of 130 (28.5%) with CTRX and in 36 out of 137 (26.3%) with CTX, no significant difference being detected.4) Usefulness: CTRX was evaluated to be very useful in 3 out of 133, useful in 94, slightly useful in 13 and useless in 20. There were 3 unevaluable cases.CTX was very useful in 2 out of 143, useful in 90, slightly useful in 14 and useless in 28. Evaluation was impossible in 9 cases.There was no significant difference in usefulness between CTRX and CTX.5) Conclusion: From the above, CTRX was considered to be clinically very useful for the treatment of infections of the lower respiratory tract like chronic respiratory tract infections and pneumonia.