부산대학교 도서관

Forty-two patients who underwent laparotomy for primary colorectal cancers, and 5 patients with be-nign diseases, were examined. Intraperitoneal wash, obtained during operation, underwent cytodiagnosis, and qualitative analysis of CEAm-RNA was performed using RT-PCR method. CEAm-RNA was positive in 19.0%, and cytodiagnosis was positive in 7.1%. In the cases of benign diseases, both CEA-mRNA and cytodi-agnosis were negative. All of the patients who showed peritoneal-disseminated metastases macroscopically, were also positive for CEAm-RNA and negative in cytodiagnosis. In one patient who was positive for CEAm-RNA and negative in cytodiagnosis, postoperative recurrence in the peritoneum was found. Consequently, determination of CEAm-RNA seemed to be more sensitive than cytodiagnosis in detecting cancer cells, and therefore, the former may be a useful method for establishing a prognosis. By clinicopathological examination, it is easy to recognize detecting cancer cells in cases of SS or above in the depth showing scattered infiltration pattern, of moderately differentiated adenocarcinoma rather than highly differentiated one, of mucous cancer, of lymph node metastasis or invasion, of liver metastasis, and of Stage II and above.