학술논문
Prolonged exposure to diphenylarsinic acid induced aberrant activation of cultured normal human cerebellar astrocytes: Phosphorylation of MAP kinases, upregulation of transcription factors and oxidative stress response factors, and secretion of glutathione / ジフェニルアルシン酸の長期ばく露によるヒト小脳由来培養正常アストロサイトの異常活性化：MAPキナーゼのリン酸化、転写因子・酸化ストレス応答因子の発現誘導、グルタチオンの分泌亢進
Document Type
Journal Article
Author
Source
Annual Meeting of the Japanese Society of Toxicology. 2020, :P-12S
Subject
Language
Japanese
Abstract
Diphenylarsinic acid (DPAA) is a non-natural organic arsenic compound detected in the well water in Kamisu, Ibaraki, Japan. People having used this well water developed cerebellar symptoms. In the present study we evaluated the aberrant activation of cultured normal human cerebellar astrocytes (NHA) by prolonged exposure to DPAA. NHA were exposed to 10 μM DPAA for 96, 144, 192, 240, or 288 h, and protein expression and glutathione secretion were evaluated. Exposure to 10 μM DPAA for 96 h little activated NHA, but it for 288 h could induce significant aberrant activation.