부산대학교 도서관

A 69-year-old female with known eosinophilic fasciitis treated using 7.5 mg/day of prednisolone (PSL) was referred to our hospital for painful skin lesions following cosmetic treatment. One month before the first clinical visit, she received injections of hyaluronic acid fillers in the corners of her mouth at a cosmetic surgery clinic. Painful erythema and indurative lesions developed at the injection sites one week later, and she received hyaluronidase injections at the cosmetic surgery clinic. Subsequently, infiltrative erythema developed at non-injected sites on her face, left upper arm, and right thigh, and she was referred to our hospital. Histopathological examination of a biopsy specimen from indurated erythema on her right thigh revealed a foreign body granuloma in the subcutaneous tissue and the lower dermis. We administered 15 mg of PSL (total PSL dose :22.5 mg/day) and her symptoms gradually improved. She is currently being followed up with a tapered dose of PSL (12 mg/day). Most reported cases of foreign body granuloma after hyaluronic acid filler injections occurred at the injection sites. However, in this case, multiple cutaneous lesions of foreign body granuloma appeared at both the injected and non-injected sites. This is a rare case and suggested an association with the underlying eosinophilic fasciitis. Skin Research, 20 : 104-109, 2021