학술논문
Comparative dose-finding study of Ofloxacin otic solution in suppurative otitis media / Ofloxacin耳用液の化膿性中耳炎に対する用量比較試験成績
Document Type
Journal Article
Author
Akihiro IKUI; Akira TONAI; Atsushi SHINKAWA; Fumiko IIDA; Ginichiro ICHIKAWA; Goro MOGI; Hideki SAITO; Hideyo ASAI; Hiroo TABE; Hirosato MIYAKE; Hiroshi TSURUMARU; Hiroshi WATANABE; Hitoshi OGINO; Isuzu KAWABATA; Kaneaki HARAGUCHI; Kaoru SATO; Katsuhiro HIRAKAWA; Katsunori FUKUDA; Kazuo KONISHI; Ken KITAMURA; Kiichi SATO; Koichi DEGUCHI; Koichi MIYAKAWA; Koichi YAMASHITA; Koji SERA; Kozo FUKAMI; Makoto SAKAI; Masaaki KUGE; Masahiro MIZUNO; Masaichi NAKAMURA; Masaru OHYAMA; Masashi WADA; Michinori KUROKAWA; Mikiko TAKAYAMA; Mitsuaki INAGAKI; Mitsuko SUETAKE; Mitsuyoshi NAKASHIMA; Mutsumi SATO; Naoya NAKAMURA; Nobuhiko ARAKI; Norio UEHARA; Shigehiro UEYAMA; Shinichi OKUMURA; Shinobu IWAMURA; Shozo KAWAMURA; Shuji KOIKE; Shunkichi BABA; Soiku WATANABE; Takashi FUKAYA; Takashi FUTAKI; Takehiko HARADA; Takehiro KOBAYASHI; Takeshi MARUO; Tetsuo ISHII; Tomonori TAKASAKA; Toru MATSUNAGA; Toshimitsu KOBAYASHI; Yasuhiro OZAKI; Yasuji TORIYAMA; Yasuo HARADA; Yasuo MISHIRO; Yasuya NOMURA; Yoshiaki NAKAI; Yoshihisa SASAKI; Yuichi KURONO; 三代 康雄; 三宅 浩郷; 上原 紀夫; 世良 公志; 中井 義明; 中島 光好; 中村 直也; 中村 雅一; 丸尾 猛; 久我 正明; 二木 隆; 佐々木 好久; 佐藤 かおる; 佐藤 むつみ; 佐藤 喜一; 出口 浩一; 原口 兼明; 原田 勇彦; 原田 康夫; 和田 昌士; 喜多 村健; 坂井 真; 大山 勝; 奥村 新一; 宮川 晃一; 小林 俊光; 小林 武弘; 小池 修治; 小西 一夫; 尾崎 康弘; 山下 公一; 岩村 忍; 川端 五十鈴; 市川 銀一郎; 平川 勝洋; 斉藤 秀樹; 新川 敦; 末武 光子; 東内 朗; 松永 亨; 植山 茂宏; 水野 正浩; 河村 正三; 浅井 英世; 深水 浩三; 深谷 卓; 渡辺 洋; 渡辺 荘郁; 生井 明浩; 田部 浩生; 石井 哲夫; 福田 勝則; 稲垣 光昭; 茂木 五郎; 荒木 伸彦; 荻野 仁; 野村 恭也; 飯田 冨美子; 馬場 駿吉; 高坂 知節; 高山 幹子; 鳥山 寧二; 鶴丸 浩士; 黒川 道徳; 黒野 祐一
Source
耳鼻と臨床 / jibi to rinsho. 1990, 36(3Supplement3):537
Subject
Language
Japanese
ISSN
0447-7227
2185-1034
2185-1034
Abstract
0.3% and 0.5% Ofloxacin otic solutions were topically administered to 170 patients with acute and chronic suppurative otits media, to determine the optimal dose. The efficacy rates of the 0.3% and 0.5% solutions, as judged by the physicians in charge were 85.9% (95% confidence interval; 75.6%-93.0%) and 89.7% (80.8%-95.5%), respectively. The difference between the two groups was not significant. The responce rates of all patients, as judged by both the physicians in charge and the committee, were similar, regardless of diagnostic category, strain of causative organism, severity or pattern (mono or polymicrobial) of infection, or solution concentration used. The elimination rates of causative organisms for both groups were 84.2% (72.1%-92.5%) and 80.0% (68.2%-88.9%), respectively. The only adverse reaction noted was one case of transient otalgia in each group. The usefulness rates, judged by the physicians in charge, were 84.7% (74.3-92.1%) and 89.7% (80.8-95.5%), respectively. No significant differences were observed. In conclusion, topical application of Ofloxacin in suppurative otitis media was judged to be highly useful, and that the 0.3% solution is sufficient to achieve this.