부산대학교 도서관

The role of serum uric acid (SUA) as an independent predictor of cardiovascular events (CVEs) is uncertain, as previous studies may not have sufficiently accounted for risk factors that are strongly related to the SUA level, such as chronic kidney disease (CKD). We examined the association between the SUA level and the incidence of CVEs in each gender without CKD. Baseline data, including the SUA level, estimated glomerular filtration rate, and urinary albumin/creatinine ratio were determined in participants from a community-based population. After the exclusion of CKD, the subjects were stratified into sex-specific quartiles of SUA (n = 15,036). A Cox regression analysis was performed to examine the sex-specific relationship between the baseline SUA level and the onset of CVEs. During a mean follow-up period of 8.8 years, there were 611 CVEs (304 in men, 307 in women). After adjusting for traditional risk factors, the hazard ratio for the onset of CVEs did not differ among the quartiles in men. In contrast, in women, a significant trend was observed. In the Japanese general population without CKD, moderately elevated SUA level is considered an independent risk factor for the onset of CVEs in women but not in men.