학술논문
Comparative Study of the Effectiveness of Mezlocillin and Ampicillin on Respiratory Tract Infection / 呼吸器感染症に対するMezlocillinとAmpicillinの薬効比較試験
Document Type
Journal Article
Author
Akihiko KUZE; Akio AOYAGI; Akio TACHIBANA; Akira ITO; Akira KINOSHITA; Akira SAITO; Akira UJIIE; Akira Yokoyama; Atsushi SAITO; Atsushi SHIMOMURA; Chie KARIBE; Eiji NAKAMURA; Eiro TSUBURA; Fumiaki UCHIHIRA; Fumio MIKI; Fumio NAGAHAMA; Fumiro TANAKA; Fusanosuke YAMASAKU; Hajime WATANABE; Haruaki ICHIMARU; Hideo AOKI; Hideo IKEMOTO; Hideo OHZEKI; Hideo SASAKI; Hidero NAKAZONO; Hidetoshi SHIBAKI; Hideyuki HASEGAWA; Hiroichi TANIMOTO; Hironobu IHARA; Hiroshi FUKUI; Hiroshi MINAMI; Hiroshi NAGANO; Hiroshi OKUBO; Hiroshi SUZUKI; Hiroshi TAKAGI; Hiroyasu KAWABE; Hiroyuki DOI; Hiroyuki KOBAYASHI; Hisashi NAKAHATA; Ichiro NAKAYAMA; Ippei FUJIMORI; Izumi HAYASHI; Jingoro SHIMADA; Junzaburo KABE; Kanzo SUZUKI; Kaori YASUDA; Kaoru OKADA; Kaoru OYAMA; Katsuhiko MATSUI; Katsuhiro OKAMOTO; Katsumi ENDO; Kazue SADAMOTO; Kazuki KONISHI; Kazunori HARADA; Kazuo KONDO; Kazuo TAKEBE; Kazutoyo KANEKO; Kazuyoshi WATANABE; Kei YAGUCHI; Keigo MAEHARA; Keiichi NAKAGAWA; Keiko IWAMOTO; Keimei MASHIMO; Keizo MATSUMOTO; Ken OSONOI; Kenichi IMAMURA; Kenji SAEKI; Kenji TAKAMATSU; Kentaro WATANABE; Kenzo SHIOTA; Kiyofumi ISHIKAWA; Kiyoko SAKAI; Kiyoshi KONNO; Kohei HARA; Kohya SHIBA; Kohzo MORI; Koichiro NAKADA; Kokichi FUKUSHIMA; Kotaro OIZUMI; Kozue KOMORI; Kunihiko SHINDO; Kuninori SUZUKI; Kunio DOBASHI; Kyuichiro SEKINE; Makio KURIHARA; Mamoru YAMADA; Masafumi KITAOKA; Masahisa OHMORI; Masakatsu NISHIDA; Masami ARAKAWA; Masami UEDA; Masao NAGASAWA; Masao NAKATOMI; Masaro KAJI; Masaru KOYAMA; Masataka KATSU; Masayuki TACHIBANA; Masumi TOMIZAWA; Michio YAMAKIDO; Michiyasu NAKANISHI; Mieko KAWAI; Mikihiko TANGO; Mitsuharu OGI; Mitsuko TAKAMURA; Mitsuo HASE; Mitsuo MASUDA; Mitsuo OBANA; Morikuni ABE; Motoichi TANAKA; Munetaka KOMORI; Naofumi SUYAMA; Naomi KODOMARI; Naoyoshi MASAKI; Nobuki AOKI; Nobuo MAEKAWA; Norichika MATSUMOTO; Norio INABA; Osamu ABE; Osamu HAGIWARA; Osamu KITAMOTO; Osamu KURIMURA; Osamu SEKINE; Rinzo SOEJIMA; Ryoichi AMITANI; Ryuzo FUEKI; Saburo KUREMATSU; Seiichi MURAKAMI; Setsuo KOBAYASHI; Shigechika KADO; Shigeharu MORIOKA; Shigeki ODAGIRI; Shigeru MATSUMOTO; Shinichi TOMIOKA; Shinji OKUI; Shinya YASUDA; Shuichiro YOSHIDA; Shunji HAYASHI; Sumio ARAI; Sumio KISHIMOTO; Sumio YAMAOKA; Tadanori KONDO; Tadashi MIYAHARA; Tadashi MIYAZAWA; Tadashi TAKIGAMI; Takaaki AKAGAWA; Takafumi YANO; Takahiko KONNO; Takashi AKIYAMA; Takashi NAKAGAWA; Takashi WATANABE; Takehisa YAMAJI; Takehito NAKABAYASHI; Takuro MATSUMOTO; Tamotsu TAKISHIMA; Tatsuo SAITO; Tatsuya OHNUKI; Tetsuharu TANAKA; Tetsuo KOMORI; Tohru NAGASAWA; Toshihiro GOTO; Toshikazu NEMOTO; Toshio HOJO; Toshio KOBAYASHI; Toshiyuki YAMAMOTO; Toyokazu TAMURA; Tsugio NAKAZAWA; Tsuneharu BABA; Yasunori TANAKA; Yasuyoshi SAKURAI; Yayoi OKAWA; Yoichi MIYAHARA; Yoichiro ICHIKAWA; Yomei HIRAGA; Yoshihiro KUMASAKA; Yoshihiro TAKIHARA; Yoshihiro TAKISHITA; Yoshimaru USUDA; Yoshinobu TAKASHIRO; Yoshio KINOSHITA; Yoshio KOBAYASHI; Yoshiro MOCHIZUKI; Yoshiro ODA; Yoshiro SAWAE; Yoshito NIKI; Yuichi KOIZUMI; Yukio NISHIMOTO; Yuruko OKAMOTO; Yutaka MOTOHASHI; 三木 文雄; 上田 雅己; 下村 惇; 中園 秀朗; 中富 昌夫; 中山 一朗; 中川 圭一; 中川 高志; 中村 栄治; 中林 武仁; 中沢 次夫; 中田 紘一郎; 中畑 久; 中西 通泰; 丹呉 幹彦; 久世 彰彦; 二木 芳人; 井原 裕宣; 今村 憲市; 今野 孝彦; 今野 淳; 伊藤 章; 佐々木 英夫; 佐伯 憲二; 内平 文章; 前原 敬吾; 前川 暢夫; 副島 林造; 加地 正郎; 勝 正孝; 北本 治; 北條 敏夫; 南 浩; 原 耕平; 原田 一紀; 可部 順三郎; 吉田 秀一郎; 土居 裕幸; 土橋 邦生; 塩田 憲三; 増田 光夫; 大久保 滉; 大山 馨; 大川 弥生; 大森 雅久; 大泉 耕太郎; 大貫 達也; 大関 秀雄; 奥井 津二; 安田 佳織; 安田 真也; 安部 理; 定本 和江; 宮原 正; 宮原 洋一; 宮沢 正; 富岡 真一; 富沢 磨須美; 小山 優; 小林 宏行; 小林 敏男; 小林 節雄; 小林 芳夫; 小森 こずえ; 小森 哲夫; 小森 宗敬; 小泉 雄一; 小泊 直美; 小田 芳郎; 小田切 繁樹; 小花 光夫; 小西 一樹; 山作 房之輔; 山岡 澄夫; 山木戸 道郎; 山本 俊幸; 山田 衛; 山路 武久; 岡本 勝博; 岡本 緩子; 岡田 薫; 岩本 恵子; 岸本 寿男; 嶋田 甚五郎; 川部 汎康; 市丸 治秋; 市川 洋一郎; 平賀 洋明; 後東 俊博; 斉藤 玲; 斉藤 篤; 斉藤 龍生; 望月 吉郎; 木下 与四男; 木下 啓; 本橋 豊; 村上 誠一; 松井 克彦; 松本 卓郎; 松本 慶蔵; 松本 法親; 松本 茂; 林 俊治; 林 泉; 柴 孝也; 柾木 尚義; 栗原 牧夫; 栗村 統; 根本 俊和; 桜井 康喜; 森 幸三; 森岡 茂治; 榑松 三郎; 横山 明; 武部 和夫; 氏家 昭; 池本 秀雄; 沢江 義郎; 河合 美枝子; 渡辺 一功; 渡辺 健太郎; 渡辺 肇; 渡辺 隆; 滝上 正; 滝下 佳寛; 滝原 義宏; 滝島 任; 熊坂 義裕; 田中 二三郎; 田中 元一; 田中 哲治; 田中 康徳; 田村 豊一; 真下 啓明; 矢口 慧; 矢野 敬文; 石川 清文; 福井 洸; 福島 孝吉; 秋山 隆司; 稲葉 宣雄; 立花 征幸; 立花 昭生; 笛木 隆三; 網谷 良一; 芝木 秀俊; 苅部 千恵; 荒井 澄夫; 荒川 雅美; 荻 光春; 萩原 修; 薄田 芳丸; 藤森 一平; 螺良 英郎; 西本 幸男; 西田 正勝; 谷本 普一; 貴田岡 正史; 賀戸 重允; 赤川 高明; 近藤 一雄; 近藤 忠徳; 進藤 邦彦; 遅野井 健; 遠藤 勝実; 酒井 浄子; 金子 和豊; 鈴木 国功; 鈴木 寛; 鈴木 幹三; 長沢 亨; 長沢 正夫; 長浜 文雄; 長谷 光雄; 長谷川 英之; 長野 準; 関根 球一郎; 関根 理; 阿部 守邦; 青木 信樹; 青木 秀夫; 青柳 昭雄; 須山 尚史; 馬場 恒春; 高城 義信; 高木 浩; 高村 光子; 高松 健次
Source
感染症学雑誌 / Kansenshogaku Zasshi. 1981, 55(4):276
Subject
Language
Japanese
ISSN
0387-5911
1884-569X
1884-569X
Abstract
To evaluate antibacterial effectiveness, safety and clinical usefulness of mezlocillin (MZPC), multi clinical comparative studies against ampicillin (ABPC) were conducted in patients with lower respiratory tract infections. The patients were treated for up to 14 days with a dose of 2 g b.i.d. of either MZPC or ABPC by drip infusion. A total of 264 patients entered the trials. A comparison of the effectiveness of both test drugs was made in 233 cases (MZPC; 111 cases, ABPC; 122 cases).An evaluation of their respective safety in 252 patients (MZPC; 120, ABPC; 132) and usefulness for 237 patients (MZPC; 113, ABPC; 124) was made.Comparison between the two treatment groups was made for all cases and stratified by diagnosis, namely, bacterial pneumonia, pneumonia group (bacterial pneumonia, mycoplasmal pneumonia, PAP and lung abscess) and R.T.I other than pneumonia.A comparison of clinical efficacy, rated MZPC in 76.6%, and ABPC treatment in 64.8% as “effective”. The difference between the two drugs in statistically significant. When patients were stratified by diagnosis, MZPC treatment showed an efficacy rate of 80.4%, and ABPC treatment of 70.0% in patients with bacterial pneumonia. In patients with pneumonia, MZPC treatment was effective in 76.6%, and ABPC treatment in 70.3% of the case load, without however any statistical difference. Comparison of the therapeutic results of the two treatment groups in patients with RTI other than pneumonia, MZPC was effective in 76.5%, and ABPC in 56.3%. The difference is statistically significant. Comparison of efficacy after stratified by severity of diseases and complications, MZPC treatment showed superiority in the group of all moderate to severe cases. On further stratification of all cases superiority of MZPC was seen in the group of moderate to severe cases of RTI other than pneumonia. When studied in connection with complications, superiority of MZPC was observed in all cases of A group complications, namely with complications which may affect the clinical course of infections and/or the therapeutic effect of the drugs, and also in the pneumonia group with A group complications.Adverse reactions attributable to the test drugs were noted in 5.0% of patients treated with MZPC and in 9.1% of those who received ABPC.MZPC treatment was rated as useful in 75.2% of patients as compared with 60.5% with ABPC, showing statistically significant superiority of MZPC over ABPC. These results justify to conclude that MZPC is a highly effective, useful and safe drug for the treatmens of lower respiratory tract infections especially for patients with intractable and/or moderate to severe infections.