부산대학교 도서관

In vitro sensitivity of gentamicin (GM) against Staphylococcus aureus and gram negative bacilli was estimated with dilution method. Determined average M. I. C. was as follow5 standard strains of staphylococcusincluding Terashima and 209 P strain: between O. 7 8 and 1. 56 mcg/ml67 strains of pathogenic staphylococcus: between O. 7 8 and 3. 12 m cg/mlE. coli NIHJ: 3. 12 mcg/mlProteus vulgaris OX 19: 6. 25 mcg/mlKlebsiella pneurnoniae ST 101: 12. 5 m cg/mlPseudomonus aeruginosa KH: 3. 12 m cg/ml87 strains of pathogenic E. coli: be tween 6. 25 and 25 mcg/ml27 strains of Proteus: between 6. 25 and 25 mcg/ml40 strains of Klebsiella: less than 6. 25 mcg/m l35 strains of Pseudomonas: between 3. 1 2 and 6. 25 mcg/mlClinically, 3 patients with urinary tract infection, 3 with biliary tract infection and one of sepsis were revealed as E. coli infection and received 80 mg i. m. injection of GM daily. To five of seven patients, GM was apparently effective and the others, it was not sensitive.As a Lonclusion, GM was an effective antibiotic against Staphylococcus aureus and gram negative bacilli, particularly against pseudomonas.