학술논문
Inhibitory effects of chemically synthesized oligosaccharides on the peritoneal dissemination. / 化学合成糖鎖による腹膜播種性転移の阻害
Document Type
Journal Article
Author
A. Okamura; H. Kuwano; I. Takai; K.L. Matta; Matta K.L.; N. Kochibe; S. Akamatsu; S. Kudo; S. Tanaka; S. Yazawa; T. Asao; T. Nishimura; 岡村 明彦; 工藤 重治; 巨智部 直久; 桑野 博行; 浅尾 高行; 田中 進; 矢澤 伸; 西村 東洋; 赤松 優; 高井 泉
Source
日本分子腫瘍マーカー研究会誌 / Japan Journal of Molecular Tumor Marker Research. 2001, 16:71
Subject
Language
Japanese
ISSN
2433-8575
Abstract
A series of chemically synthesized oligosaccharides have been examined for developing drags which show anti-peritoneal dissemination activities using mouse greater omentum and gastric and colorectal cancer cells. A new ex vivo assay method has also been developed and it could be conveniently used for evaluation of each oligosaccahride with a relatively longer incubation period. Galβ1, 3[3OMeGalβ1, 4GlcNAcβ1, 6] αBn was found to possess the strongest anti-adhesion activity bewteen MKN 45, colon26 cells and greater omentum even though the compound did not show any anti-proliferation activities against those cells at all. Further, the formation of tumors in the greater omentum of Balb/c mice which were intraperitoneally inoculated with colon26 and Galβ [3OMeGalβ 1, 4GlcNAcβ1, 6] GalNAcαBn was observed to be significantly reduced in comparison with that in mice inoculated only with colon26. It must therefore be possible to develop anti-adhesion therapy with this novel oligosaccahride.