학술논문
Hydrogen sulfide increases intracellular Ca2+ concentration by inhibition of mitochondrial respiration in cultured rat spinal cord astrocytes. / ラット脊髄アストロサイトにおけるH2Sによる好気呼吸抑制を介した細胞内Ca2+上昇
Document Type
Journal Article
Author
Source
Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2021, :3-5
Subject
Language
Japanese
ISSN
2435-4953
Abstract
Na2S (150 µM) increased [Ca2+]i, which was inhibited by rotenone, an ETC inhibitor, and FCCP, an uncoupler of oxidative phosphorylation. Na2S also increased extracellular lactate, and decreased intracellular ATP content when glycolysis was inhibited by iodoacetic acid. The increase in both Ca2+ and extracellular lactate by Na2S were inhibited by emetine, an inhibitor of translocon complex, which mediates Ca2+ leak from the ER.