부산대학교 도서관

A 22 year old man with severe aplastic anemia (AA) who already became refractory to platelet transfusions has been successfully treated by allogeneic bone marrow transplantation (BMT).He was diagnosed as mild AA at 6 years before BMT. Treatment with prednisolone, mepitiostane, methyl-prednisolone and anti-lymphocyte globulin failed to be effective, and AA became to be severe gradually. He transfused more than 300 unit of blood, and bacame to be refractory to platelet transfusions. Therefore, platelet and lymphocyte crossmatch was performed borore BMT, and 6 matched platelet donors among 400 persons were selected for platelet pheresis.At May 9 1985, he was transplanted bone marrow from HLA identical brother after the premedication of high dose cyclophosphamide and total lymphoid irradiation. Cyclosporin was given for the prevention of graft versus host disease. Prompt engraftment of bone marrow and recovery of peripheral blood leukocyte and platelet were observed. Crossmatch negative platelet transfusions were effective and no hemorrhagic tendency had occurred during BMT. Patient is surviving with almost normal hematopoiesis and with good clinical conditions more than two years after BMT.