학술논문
Renal Function-Dependent Associations of Statins with Outcomes of Ischemic Stroke
Document Type
Journal Article
Author
Chaur-Jong Hu; Cheng-Li Lin; Cheng-Yu Wei; Chien-Chung Chen; Chih-Hung Chen; Ching-Huang Lin; Chung Y. Hsu; Chung-Hsiang Liu; Huey-Juan Lin; Jiann-Shing Jeng; Li-Kai Tsai; Li-Ming Lien; Pai-Hao Huang; Po-Lin Chen; Shih-Pin Hsu; Shin-Joe Yeh; Sung-Chun Tang; Ta-Chang Lai; Yu Sun; and Taiwan Stroke Registry Investigators
Source
Journal of Atherosclerosis and Thrombosis. :55210
Subject
Language
English
ISSN
1340-3478
1880-3873
1880-3873
Abstract
Results: Statin therapy at discharge was associated with lower risks of mortality (adjusted hazard ratio [aHR], 0.41; 95% confidence interval [CI], 0.34 to 0.50) and unfavorable functional outcomes (mRS 3–5; aHR, 0.80; 95% CI, 0.76 to 0.84) in ischemic stroke patients. After stratification by eGFR, the lower risk of mortality associated with statins was limited to patients with an eGFR above 15 mL/min/1.73 m2. Using statins at discharge was correlated with a lower risk of unfavorable functional outcomes in patients with an eGFR of 60–89 mL/min/1.73 m2. Statin therapy in patients with an eGFR of 60–89 mL/min/1.73 m2 may be associated with a higher risk of recurrent ischemic stroke compared with nonusers (aHR, 1.29; 95% CI, 1.07 to 1.57).