부산대학교 도서관

Among 397 patients undergoing surgery for breast cancer, 226 patients were carried out hypotensive anesthesia administering through dripping intravenous infusion of a 0.1-0.05% solution of trimethaphan (Arfonad®) in order to investigate the safety and utility of hypotensive anesthesia. In this report, the bleeding volume and urine volume during the operation under hypotensive anesthesia, and the effect on operation time and anesthesia time were studied. In all cases general anesthesia was conducted by a modified NLA in order to regulated the systolic blood pressure between 80 and 100mmHg. The bleeding volume during the operation was 114.10±79.30ml (mean±S.D.) in the hypotensive anesthesia group and 627.54±234.79ml in the non-hypotesive anesthesia group. Thus a clear and marked reduction in bleeding volume was observed in the hypotensive group. The urine volume during the operation was 1.91±1.09ml/min. in the hypotensive group and 2.77±1.61ml/min. in the nonhypotensive group. Thus the reduction in urine volume was clearly observed in the hypotensive group, resulting no abnormality as oliguria or anuria. The operation time was 130.26±29.2 min. in the hypotensive group and 142.18±32.43min. in the non-hypotensive group, so that a curtailment of operation time was markedly observed in the hypotensive group. In the hypotensive anesthesia group a tendency was observed for a shortening of the anesthesia time, but there was no significant difference as the operation time showed. In the hypotensive group no patient required blood transfusion during the operation, so that there was no danger of hepatitis dut to blood transfusion. Based on the above results, it can be said that hypotensive anesthesia, if adequately regulate the hypotensive condition, is an excellent method for as a countermeasure in preventing the loss of blood during an operation.