학술논문
A dose-finding study of nasal Fosfomycin (FOM) for the treatment of sinusitis / 鼻科用Fosfomycin (FOM) の副鼻腔炎に対するネブライザー療法による用量設定比較試験
Document Type
Journal Article
Author
Akiko NISHIYAMA; Akira YOKOTA; Akiyasu UCHIZONO; Atsushi KOMATSUZAKI; Chiyonori INO; Fumikazu MIZUKOSHI; Goro MOGI; Haruhiko NAKAMURA; Hideyo ASAI; Hideyuki KAWAUCHI; Hirosato MIYAKE; Hiroshi MATSUURA; Hiroshi TAKENAKA; Hiroyuki YOSHIMURA; Hitoshi SAITO; Jun-ichi BUNDOU; Junko TAKADA; Katsuhiro HIRAKAWA; Katsuya AKIOKA; Kazuhiro OTA; Kazuo SATO; Keiichi DATE; Keiji MORIYA; Kenji SAKAKURA; Kentaro ASHIDA; Kohji YUTA; Kohnosuke WAKUTA; Kouichi USHIRO; Kouji AJISAKA; Koukichi HAMAGUCHI; Makoto HYUGA; Mariko TANAKA; Masako YOKOTA; Masaru OYAMA; Michihiko OGATA; Mitsuie MASITTIA; Mitsuyoshi NAKAJIMA; Naoya MIYAMOTO; Natsuki MORISHIMA; Nizo TAKANAMI; Norikazu SUGIURA; Noritsugu KANEDA; Reiki YAGATA; Reiko KASHIWAGI; Satoshi SAIDA; Shigeharu FUJIEDA; Shubun TAKEBAYASHI; Shunkichi BABA; Souiku WATANABE; Tadao NISHIMURA; Takao SONODA; Takashi MATSUNAGA; Takehiro KOBAYASHI; Takeshi KUBO; Takuo NOBORI; Tamotsu MORIMITSU; Tatsuya OKUZONO; Tatsuyuki FUKUSHIMA; Tomio TERAZONO; Tomomi ITAYA; Toru MATSUNAGA; Toru SEKITANI; Toshihiko MAEDA; Toshikazu TOKUDA; Toshiko KAMIHATA; Toshio YAMASHITA; Tsuneo YOSHIKAWA; Tsutomu MATSUZAKI; Wataru OSHIMA; Yasuhiro MIYAZAKI; Yasuo HARADA; Yasuo IWABUCHI; Yasuo SAKAKURA; Yasushi MURAKAMI; Ynirhi OGATA; Yoshiaki KAWASAKI; Yoshiaki NAKAI; Yoshihiro OHASHI; Yoshiko OKUZONO; Yuichi MAJIMA; Yukio ETOH; Yuko KOBAYASHI; 三宅 浩郷; 中井 義明; 中島 光好; 中村 晴彦; 久保 武; 井野 千代徳; 伊達 敬一; 佐藤 一雄; 内薗 明裕; 分藤 準一; 前田 稔彦; 原田 康夫; 吉川 恒男; 吉村 弘之; 和久田 幸之助; 園田 隆郎; 坂倉 健二; 坂倉 康夫; 増田 光家; 大山 勝; 大島 渉; 大橋 淑宏; 太田 和博; 奥園 美子; 奥園 達也; 守谷 啓司; 宮崎 康博; 宮本 直哉; 寺薗 富朗; 小松崎 篤; 小林 優子; 小林 武弘; 山下 敏夫; 岩淵 康雄; 川内 秀之; 川嵜 良明; 平川 勝洋; 徳田 寿一; 斎田 哲; 斎藤 等; 日向 誠; 昇 卓夫; 杉浦 欣一; 村上 泰; 松崎 勉; 松永 亨; 松永 喬; 松浦 宏司; 板谷 知巳; 柏木 令子; 森島 夏樹; 森満 保; 横田 明; 横田 雅子; 水越 文和; 浅井 英世; 浜口 幸吉; 渡辺 荘郁; 湯田 厚司; 牛呂 公一; 田中 真理子; 矢形 礼貴; 神畠 俊子; 福島 龍之; 秋岡 勝哉; 竹中 洋; 竹林 脩文; 緒方 洋一; 緒方 道彦; 芦田 健太郎; 茂木 五郎; 藤枝 重治; 衛藤 幸男; 西山 彰子; 西村 忠郎; 金田 規嗣; 間島 雄一; 関谷 透; 馬場 駿吉; 高波 二三; 高田 順子; 鰺坂 孝二
Source
耳鼻と臨床 / jibi to rinsho. 1995, 41(2):218
Subject
Language
Japanese
ISSN
0447-7227
2185-1034
2185-1034
Abstract
We performed a dose-finding study on nasal FOM, as an antibiotics for nebulization, in the treatment of an acute exacerbation of chronic sinusitis and compared this treatment with the oral administration of FOM as a control group and the follwing results were obtained; The rate of clinical efficacy was 85%in the 3%group, 76%in the 5%group and 57%in the transoral group-There was a significant difference between the 3%and the transoral group, There were no siginificant differences between the 5%group and the transoral group, or between the 3%and the 5%groups. Neither the biological eradication rate nor the radiological improvement rate showed any significant difference among the groups The incidence of adverse reactions was 2%, 5%, and 31%in each group, respectively. The differences between the nebulization group and the transoral group were significant. Abnormal laboratory findings were observed in 5 cases, but only in the transoral group. The rates of usefulness were 83%, 73% and 44% in each group. There were significant differences between the nebulization group and the transoral group. The above results indicated that the nebulization of FOM for sinusitis was useful in comparison to oral administration. In addition, no significant difference was observed between the 3%and the 5% nebulization groups with any of the results presented above. We thusconcluded that 3%was the optimal concentration of nasal FOM for sinusitis.