학술논문
Adult T-cell Leukemia (ATL) Cells which Express Neural Cell Adhesion Molecule (NCAM) and Infiltrate into the Central Nervous System
Document Type
Journal Article
Author
Source
Internal Medicine. 2002, 41(1):34
Subject
Language
English
ISSN
0918-2918
1349-7235
1349-7235
Abstract
We encountered a patient with adult T-cell leukemia/lymphoma (ATL) which expressed neural cell adhesion molecule (NCAM). The tumor cells markedly infiltrated the central nervous system (CNS) during the course of the ATL. The patient died 20 months after disease onset, which was considered to be early in the course. During the invasion of the CNS, the surface phenotype of the peripheral blood ATL cells by flow cytometric analysis was CD2+, CD3+, CD4+, CD7-, CD8-, CD16-, NCAM (CD56)+, HLA-DR-. We speculate that the infiltration of ATL cells into the CNS was closely related to the expression of the NCAM in this patient.(Internal Medicine 41: 34-38, 2002)