학술논문
Breast cancer recurrence in a spared nipple areola 15 years postoperatively NSM in a woman with BRCA2 pathogenic variant: a case report and literature review / 乳頭温存乳房全切除術施行15年後に温存乳頭直下に乳癌を生じたBRCA2病的バリアントを有する乳癌の1例
Document Type
Journal Article
Author
Source
遺伝性腫瘍 / Journal of Hereditary Tumors. 2023, 23(1):38
Subject
Language
Japanese
ISSN
2435-6808
Abstract
We report a case of breast cancer in the nipple-areola component after Nipple-sparing mastectomy（NSM） with a pathogenic variant of BRCA2. The patient was a 49-year-old woman. At the age of 33, she underwent NSM and axillary dissection for left breast cancer pT3N1M0 Stage ⅢA, and the resection margins were negative. At the age of 43, she underwent NSM for right breast cancer pTisN0M0 Stage 0. At the age of 49, she came to hospital because she was aware of a mass just below the left nipple. A hypoechoic mass of 5.3 mm in size was found on ultrasonography, and left breast cancer was diagnosed by excisional biopsy. A total excision including the left nipple and areola was performed as a radical surgery. Genetic testing performed due to 3 breast cancers under age 50. The results of the genetic testing showed that pathogenic variant of c.9076C>T (p.Gln3026*) in BRCA2.