부산대학교 도서관

A 62-year-old female was referred to our hospital for examination of a skin lesion on her left epigastric region, which developed 6 years before her first visit to our hospital. Orange-yellow or red papules aggregated and fused to form a slightly hard, shiny plaque on her left epigastric region. Furthermore, soft, partly wrinkled, and skin-colored or pink nodules developed on her left vulva 2 years before her visit. Histopathological examination of both skin lesions revealed amyloid deposition derived from immunoglobulin light chain kappa. Around the same time, she visited the department of urology for pain in her genital area and was diagnosed with bladder amyloidosis. Amyloid deposition was confirmed in her skin and bladder, but she was diagnosed with localized amyloidosis based on the amyloid-deposited organs, laboratory findings, and clinical course. The skin lesions on her epigastric region and vulva exhibited different clinical features, but both lesions were diagnosed as localized cutaneous nodular amyloidosis due to the histopathological findings. According to previous reports, localized cutaneous nodular amyloidosis exhibits many clinical features, and it may be overlooked in daily medical practice. Skin Research, 20 : 299-308, 2021