부산대학교 도서관

Despite extensive investigation and speculation, the pathophysiology of the eosinophilia associated with orgonic involvements remains largely unknown.This case report was concerned with a 27-year-old male who showed initially the edema in the lower extremities, hypertension, and proteinuria, following by a leukocytosis due primarily to increased numbers of mature eosinophils, cardiac insufficiency, renal insufficiency, and hepatosplenomegaly during a course. A sternal aspiration revealed normal in cellularlity with slight increase of eosinophilic elements. The cytogenetic abnormality in bone marrow cells was not demonstrated and neutrophil alkaline phosphatase showed normal range in the activity. Consequently it was difficult to diagnose as eosinophilic leukemia. On the other hand, there was a decrease of serum protein, no significant results in various immuno-serological studies. The biopsy specimen from the skin and muscle also disclosed no fibrinoid degeneration of collagen fibers.In 1968 Hardy proposed the term “Hypereosinophilic syndrome” to encompas the entire group, Loeffler's syndrome, Loeffler's endocarditis, disseminated eosinophilic collagen disease, eosinophilic leukemia and so on.From the available evidence this case has closer relationship to the concept of hypereosinophilic syndrome.