학술논문
Significance of carbohydrate 6-sulfotransferases in colon cancer. / 大腸癌における糖鎖6-硫酸基転移酵素の発現と生理的意義
Document Type
Journal Article
Author
Source
日本分子腫瘍マーカー研究会誌 / Japan Journal of Molecular Tumor Marker Research. 2001, 16:58
Subject
Language
Japanese
ISSN
2433-8575
Abstract
Previously we showed that the sialyl 6-sulfo Lex determinant, the L-selectin ligand on high endothelial venules in lymph nodes, is also expressed in human colonic tissues. The sialyl 6-sulfo Lex determinant was preferentially expressed in non-malignant colonic epithelia than in cancer cells. We next investigated the amount of mRNA for 6-sulfotransferases (6ST) isoenzymes in human colorectal cancer tissues. The most remarkable finding was that the message of HEC-GlcNAc6ST was prominently increased in cancer tissues compared to nonmalignant mucosa. On the other hand, I-GlcNAc6ST mRNA expression was significantry higher in non-malignant mucosa rather than in cancer tissues.