부산대학교 도서관

Thirty-five osteoporotic women, with a mean age of 69 years (range, 58-86 years), were treated by our “long-cycle” ADFR regime according to Frostian concept. Frostian concept is a rational therapeutic approach to manipulating the basic ARF sequence, named ADFR treatment. The effect of ADFR treatment on bone mass in osteoporotic women was examined at orgen level in this study.Each cycle of our ADFR treatment consists of a) activation by 1α-OH-D3 (1.5μg/day), b) depression by calcitonin (10 ECU Elcatonin two times a week), c) free or low dose administration of 1α-OH-D3 (0.25μg/day) and d) repeat of this ADF regime. The bone mineral mass of the distal 1/6 site of the radius was monitored using 125-I single photon absorptiometry, knowing when and how long to give and when to withdraw the drugs.Not all patients responded alike to the ADFR treatment. An increase of bone mass following atemporary decrease was found in 24 (69%) of 35 patients, but in 11 patients bone mass did not change consistently. The increase of bone mass in responder group was about 9% of the value before treatment.The significant difference of the bone mineral status before starting therapy in two groups was detected. In responder group, 1/6/1/3 ratio of initial BMC/BW value was low, but high in non-responder group.