학술논문
Waldenström macroglobulinemia complicated by peripheral neuropathy due to neural infiltration / 神経浸潤による末梢神経障害を合併した原発性マクログロブリン血症
Document Type
Journal Article
Author
Akiko ISHII; Akira TAMAOKA; Hana TAKAHASHI; Hidekazu NISHIKII; Kiyotaka NAKAMAGOE; Mamiko SAKATA-YANAGIMOTO; Naoki KURITA; Naoshi OBARA; Natsuki NORIOKA; Ryota MATSUOKA; Shigeru CHIBA; Takayasu KATO; Tatsuhiro SAKAMOTO; Toru NANMOKU; Yasuhisa YOKOYAMA; Yuya KAMURA; 中馬越 清隆; 加村 雄哉; 加藤 貴康; 千葉 滋; 南木 融; 坂本 竜弘; 坂田（柳元） 麻実子; 小原 直; 松岡 亮太; 栗田 尚樹; 横山 泰久; 法岡 菜月; 玉岡 晃; 石井 亜紀子; 錦井 秀和; 高橋 華
Source
臨床血液 / Rinsho Ketsueki. 2023, 64(1):18
Subject
Language
Japanese
ISSN
0485-1439
1882-0824
1882-0824
Abstract
A 51-year-old man with the chief complaint of glove- and stocking-type dysesthesia for >3 years was diagnosed with Waldenström’s macroglobulinemia (WM) based on IgM-type M-proteinemia, bone marrow infiltration of plasmacytoid B cells, multiple lymphadenopathies, and splenomegaly. A nerve conduction examination suggested demyelinating neuropathy. Serum anti-myelin—associated glycoprotein antibody was negative. Sural nerve biopsy showed myelin thinning, suggesting demyelination. Axonal damage and tumor cell infiltration in the intrafascicular epineurium were also observed. After chemotherapies with rituximab and bendamustine, M-proteinemia and lymphadenopathies disappeared. However, abnormalities in the nerve conduction examination and dysesthesia were only slightly alleviated. As articles describing patients with WM with peripheral nerve infiltration are limited, we report this case with a literature review.